Undruggable registry

Cross-session targets blocked from direct modulation

Cross-session learning

Targets where direct modulation is not pursued

Arclight records targets that fail three-modality druggability screening. Future discovery programs inherit this registry automatically — avoiding repeated dead-end routes. Rescan-eligible entries may be reconsidered on a manual target re-screen; automatic literature monitoring is not active yet.

Registry entries

0

Unique targets

0

Global blocks

0

Rescan eligible

0

How the registry is used

During Phase 2 target screening, entries here pre-block targets before expensive drug-branch steps run. Session assessments are promoted into this list when a primary target fails across small molecule, biologic, and ADC modalities. Global entries apply to all future discoveries.

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